Harmony Prenatal Test

The Harmony Prenatal Test is a DNA-based blood test for Down Syndrome. Harmony is more accurate than traditional tests, can be performed as early as 10 weeks in pregnancy and results come back within 7 – 10 working days.

Appointments are 45 minutes to hour long and include a viability scan and a blood test, from the mothers arm.

Some genetic conditions run in families while others, like Down Syndrome, typically do not. They can happen in any pregnancy. Although the risk of Down syndrome increases with age, most babies born with Down syndrome are born to women under 35.

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What is the Harmony Test?

When you’re pregnant, your blood contains fragments of your baby’s DNA. The Harmony Test is a type of test that analyses this DNA in a sample of your blood to assess the risk of:

  • Down syndrome (trisomy 21)
  • Edwards syndrome (trisomy 18)
  • Patau syndrome (trisomy 13)

For all women

Traditional screening tests can miss as many as 15% of Down Syndrome cases in pregnant women. Harmony was developed to be a more accurate prenatal Down Syndrome screening test for all women, regardless of age or risk. It is a new DNA-based blood test that has been extensively tested in pregnant women both over and under 35.

A more accurate test

Conventional screening will detect approximately 70-80% of pregnancies with Down syndrome. The Harmony test will detect over 99%.

Harmony has a false positive rate of less than 0.1% compared to the 5% with conventional screening. This means that the Harmony test detects more pregnancies with Down syndrome but also reduces the risk of unnecessary amniocentesis.

Clarity early

Harmony Test requires a single blood sample from your arm and can be done as early as 10 weeks or later in pregnancy. The results will take between 7-10 working days to come through. Other commonly used tests for Down syndrome are performed later in pregnancy and require multiple clinic visits.

Minimises need for follow-up tests

The greater accuracy and low false-positive rate of Harmony compared to the traditional tests minimises the number of high risk results. Therefore fewer women will need follow up testing using an invasive procedure, such as amniocentesis.

Fetal sex chromosomes

Harmony Prenatal Test can also be used to evaluate X and Y sex chromosomes as early as 10 weeks. You have the option to test for conditions caused by having an extra of missing copy of the X or Y chromosomes, including Turner and Klinefelter syndromes. (This is only available for singleton pregnancies).

Does a low risk result mean that the baby does not have Down syndrome?

No, any screening test carries a risk of a ‘false negative’ however the risk of this happening with the Harmony is much lower than with conventional Down screening.

If I have a high risk result does that mean that the baby’s chromosomes are abnormal?

No, not necessarily. It means that there is a higher risk and you will be offered the option of amniocentesis to assess the chromosomes directly. You will be offered support and counselling to help you reach that decision.

What if I have twins?

The Harmony Non Invasive Prenatal Test and technology can also be applied to twin pregnancies but is not suitable in the case of a vanishing twin.

Will I always get a result?

3 out of 100 women will require a repeat test. We receive a result in approximately two thirds of these samples. Patients will not be charged if we are unable to obtain a result.

Your Results

You will receive the results within 7 -10 working days of your blood test. The test result will give you a clear answer about the risk to your pregnancy of having any of the genetic conditions included in the test. All results will be given to you by the Clinic and will be interpreted in the context of your medical details and family history. You should continue with your usual scan appointments before and following testing.

Non-invasive prenatal testing based on cell-free DNA analysis is not considered diagnostic.

What Private Maternity Scans are available at the Surrey Park Clinic?

A private pregnancy scan can be booked to not only provide reassurance, but should you have symptoms such as pelvic pain, or bleeding in pregnancy can be very worrying. Whilst the symptoms may not be severe enough for your GP to feel that a scan is justified, it nevertheless may be very helpful to have a private scan of the affected area in order to rule out a problem.

As a private clinic we are able to offer scans 6 days a week and same day in our comfortable and discreet clinic.

  • Early Pregnancy Scan £170
  • From 6 weeks 20 minute appointment, determine viability, gestation and date of your baby. Includes estimated due date, full report including measurements and up to 4 pictures on a mounted frame.
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  • Gender Scan £99
  • From 16 weeks, 20 minute appointment, gender reveal, full report and up to 4 pictures on a mounted frame
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  • Growth Scan £205
  • From 16 weeks, 20 minute appointment, growth measurement, weight estimate and umbilical cord Doppler measurement, gender reveal if requested, full report and up to 4 pictures on a mounted frame
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  • Harmony Screening £450
  • From 10 weeks, 45 minute appointment includes Early Pregnancy scan, 15 minute nurse consultation and blood test to determine Down syndrome, Edwards Syndrome, Patau syndrome risk and Gender is requested.
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